Cross-Talk between Peroxisome Proliferator- Activated Receptor (PPAR) and Liver X Receptor (LXR) in Nutritional Regulation of Fatty Acid Metabolism. I. PPARs Suppress Sterol Regulatory Element Binding Protein-1c Promoter through Inhibition of LXR Signaling
نویسندگان
چکیده
Department of Metabolic Diseases (T.Y., N.Y., M.A.-K., T.K., H.O., Y.T., M.S., A.H.H., J.O., S.I.), Faculty of Medicine, Department of Applied Biological Chemistry (R.S.), Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; and Department of Internal Medicine (T.I., H.S., T.M., S.Y., A.T., H.S., N.Y.), Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305-8575, Japan
منابع مشابه
Cross-Talk between Peroxisome Proliferator- Activated Receptor (PPAR) and Liver X Receptor (LXR) in Nutritional Regulation of Fatty Acid Metabolism. II. LXRs Suppress Lipid Degradation Gene Promoters through Inhibition of PPAR Signaling
Fatty acid metabolism is transcriptionally regulated by two reciprocal systems: peroxisome proliferator-activated receptor (PPAR) controls fatty acid degradation, whereas sterol regulatory element-binding protein-1c activated by liver X receptor (LXR) regulates fatty acid synthesis. To explore potential interactions between LXR and PPAR, the effect of LXR activation on PPAR signaling was invest...
متن کاملEffects of fatty acids on gene expression: role of peroxisome proliferator-activated receptor α, liver X receptor α and sterol regulatory element-binding protein-1c
Abbreviations: LXR, liver X receptor; PPAR, peroxisome proliferator-activated receptors; PUFA, polyunsaturated fatty acids; SREBP, sterol regulatory element-binding protein. Corresponding author: Dr Sander Kersten, fax + 31 317 483342, email [email protected] CAB InternationalPNSProceedings of Nutrition Society (2002)0029-6651© Nutrition Society 2002 613 PNS 169Nutr e t regulat...
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